Локальный иммунитет при хроническом гастродуодените у детей
DOI:
https://doi.org/10.61699/cjmps-v2-i3-4-p46-62Ключевые слова:
хронический гастродуоденит, иммунитет, детиАннотация
Проведен анализ литературных данных о роли локального иммунного ответа в патогенезе хронического гастродуоденита у детей. В настоящее время наметилась стойкая тенденция к росту гастроэнтерологических заболеваний среди детей. Наибольшая вероятность проявления гастроэнтерологических заболеваний приходится на 3-6 и 9-12 лет. У 40-60% взрослых гастроэнтерологические заболевания берут своё начало в детском возрасте. С этих позиций возникает необходимость дальнейшего изучения причинно-значимых факторов в развитии патологии органов пищеварения у детей, особенностей её течения. В данной статье обсуждается роль локальной иммунной системы в патогенезе хронических гастродуоденитов. Основу хронического гастрита составляет воспаление, неотъемлемой частью которого является местная иммунная реакция. Сущность её состоит в инфильтрации слизистой оболочки желудка плазмоцитами, лимфоцитами, гистиоцитами с увеличением количества макрофагов, фибробластов, эозинофилов, тучных клеток, МЭЛ. Степень лимфоплазмоцигарной инфильтрации отражает тяжесть воспаления.
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