The role of local immunity in chronic gastroduodenitis in children
DOI:
https://doi.org/10.61699/cjmps-v2-i3-4-p46-62Keywords:
chronic gastroduodenitis, immunity, childrenAbstract
An analysis of literature data on the role of local immune response in the pathogenesis of chronic gastroduodenitis in children was carried out. A persistent trend of increasing incidence of gastroenterological illnesses in children has been observed at the present time. The greatest probability of manifestation of gastroenterological illnesses occurs at ages 3-6 and 9-12. In 40-60% of adults, gastroenterological illnesses originate in childhood. For this reason, it is necessary to study the initiating and causative factors in in the development of digestive organ pathologies in children, and especially their progress. This article discusses the role of the local immune system in the pathogenesis of chronic gastroduodenitis. Inflammation lies at the core of chronic gastritis, and an integral part of it is local immune reaction. Its essence is the infiltration of the mucous membrane of the stomach by plasmocytes, lymphocytes, histiocytes, with an increase in the quantity of macrophages, fibroblasts, eosinophils, mast cells, intraepithelial lymphocytes (IEL). The degree of lymphoplasmacytic infiltration reflects the gravity of the inflammation.
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